Astaxanthin and Uric Acid Research

Astaxanthin and Uric Acid Research

Astaxanthin is an antioxidant that gives seafood a pink color. Commercial astaxanthin supplements are usually derived from microalgae. Natural sources are mainly salmon, trout, krill, shrimp and crayfish/crawfish.

Astaxanthin and Uric Acid Research Topics

Shrimp Shell Extract Reduces Uric Acid
Sila A, Ghlissi Z, Kamoun Z, Makni M, Nasri M, Bougatef A, Sahnoun Z. Astaxanthin from shrimp by-products ameliorates nephropathy in diabetic rats. Eur J Nutr. 2015 Mar;54(2):301-7. Epub 2014 May 13. PMID: 24821271.

Conclusion: In diabetic rats, urea, creatinine and uric acid levels were significantly higher in plasma (49, 58 and 16 %, respectively) comparing to the control ones (Table 2). The administration of astaxanthin to diabetic rats significantly reversed these changes to near normal values

Algae Astaxanthin Extract Has No Effect on Uric Acid
Klinkenberg LJ, Res PT, Haenen GR, Bast A, van Loon LJ, van Dieijen-Visser MP, Meex SJ. Effect of antioxidant supplementation on exercise-induced cardiac troponin release in cyclists: a randomized trial. PLoS One. 2013 Nov 19;8(11):e79280. PMID: 24260184; PMCID: PMC3834092.
This is a study of healthy humans. But not gout sufferers. So uric acid was not raised prior to treatment.

Astaxanthin Alternative to Allopurinol
In this study commercial astaxanthin supplement reduced high uric acid to normal.
Le Y, Zhou X, Zheng J, Yu F, Tang Y, Yang Z, Ding G, Chen Y. Anti-Hyperuricemic Effects of Astaxanthin by Regulating Xanthine Oxidase, Adenosine Deaminase and Urate Transporters in Rats. Mar Drugs. 2020 Dec 1;18(12):E610. PMID: 33271765.

Conclusion: Astaxanthin decreased the serum UA [Uric Acid] level by reducing the UA synthesis [like allopurinol] and promoting the UA excretion [uricosuric].

Astaxanthin Seafood for Uric Acid
What is your favorite Astaxanthin Seafood for Uric Acid?

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