Astaxanthin is an antioxidant that gives seafood a pink color. Commercial astaxanthin supplements are usually derived from microalgae. Natural sources are mainly salmon, trout, krill, shrimp and crayfish/crawfish.
Astaxanthin and Uric Acid Research Topics
- Shrimp Shell Extract Reduces Uric Acid
Sila A, Ghlissi Z, Kamoun Z, Makni M, Nasri M, Bougatef A, Sahnoun Z. Astaxanthin from shrimp by-products ameliorates nephropathy in diabetic rats. Eur J Nutr. 2015 Mar;54(2):301-7. Epub 2014 May 13. PMID: 24821271.
Conclusion: In diabetic rats, urea, creatinine and uric acid levels were significantly higher in plasma (49, 58 and 16 %, respectively) comparing to the control ones (Table 2). The administration of astaxanthin to diabetic rats significantly reversed these changes to near normal values
- Algae Astaxanthin Extract Has No Effect on Uric Acid
Klinkenberg LJ, Res PT, Haenen GR, Bast A, van Loon LJ, van Dieijen-Visser MP, Meex SJ. Effect of antioxidant supplementation on exercise-induced cardiac troponin release in cyclists: a randomized trial. PLoS One. 2013 Nov 19;8(11):e79280. PMID: 24260184; PMCID: PMC3834092.
This is a study of healthy humans. But not gout sufferers. So uric acid was not raised prior to treatment.
- Astaxanthin Alternative to Allopurinol
- In this study commercial astaxanthin supplement reduced high uric acid to normal.
Le Y, Zhou X, Zheng J, Yu F, Tang Y, Yang Z, Ding G, Chen Y. Anti-Hyperuricemic Effects of Astaxanthin by Regulating Xanthine Oxidase, Adenosine Deaminase and Urate Transporters in Rats. Mar Drugs. 2020 Dec 1;18(12):E610. PMID: 33271765.
Conclusion: Astaxanthin decreased the serum UA [Uric Acid] level by reducing the UA synthesis [like allopurinol] and promoting the UA excretion [uricosuric].
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